Dr Cecile King

About me

Associate Professor Cecile King, Ph.D., joined the School of Biotechnology and Biomolecular Sciences at the University of New South Wales Sydney in 2021. CK received her Ph.D. in Immunology from UWA and completed her postdoctoral training at the Scripps Research Institute, La Jolla, USA. She joined the faculty of the Garvan Institute for Medical Research, Sydney, Australia in 2005. CK continues to be intrigued by how the immune system maintains tolerance to self and has made important contributions to our understanding of adaptive immune responses and autoimmunity. CK’s current research focus is RNA at the immune interface: Understanding both immune recognition of RNA and immune regulation by non-coding RNA and transposable elements.

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Phone

+61 2 9348 0789

E-mail

c.king@unsw.edu.au

Location

Room 420C, Level 4 Biological Sciences Building North, D26

Books | 2020

King C, 2020, Follicular Helper T Cells in Immunity and Autoimmunity,
Book Chapters | 2000

King C; Stewart GA; Thompson PJ; Robinson C; McWilliam AS, 2000, 'Potential consequences of interactions between aeroallergens and cells within the respiratory tree', in Gehr P; Heyder J (ed.), Particle-Lung Interactions, Marcel Dekker Inc, New York, U.S.A., pp. 491 - 518,
Journal articles | 2023

Zeraati M; Ross SE; Aghaei B; Rajal AG; King C; Dinger ME, 2023, 'Protocol for the production and purification of an i-Motif-specific nanobody', STAR Protocols, 4,

Journal articles | 2022

Balachandran H; Phetsouphanh C; Agapiou D; Adhikari A; Rodrigo C; Hammoud M; Shrestha LB; Keoshkerian E; Gupta M; Turville S; Christ D; King C; Sasson SC; Bartlett A; Grubor-Bauk B; Rawlinson W; Aggarwal A; Stella AO; Klemm V; Mina MM; Post JJ; Hudson B; Gilroy N; Konecny P; Ahlenstiel G; Dwyer DE; Sorrell TC; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA, 2022, 'Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses', Cell Reports, 38, pp. 110345,

Journal articles | 2022

Bartonicek N; Rouet R; Warren J; Loetsch C; Rodriguez GS; Walters S; Lin F; Zahra D; Blackburn J; Hammond JM; Reis ALM; Deveson IW; Zammit N; Zeraati M; Grey S; Christ D; Mattick JS; Chtanova T; Brink R; Dinger ME; Weatheritt RJ; Sprent J; King C, 2022, 'The retroelement Lx9 puts a brake on the immune response to virus infection', Nature, 608, pp. 757 - 765,

Journal articles | 2022

Kurtović M; Piteša N; Bartoniček N; Ozretić P; Musani V; Čonkaš J; Petrić T; King C; Sabol M, 2022, 'RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines', Cancers, 14,

Journal articles | 2021

King C; Sprent J, 2021, 'Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation', Trends in Immunology, 42, pp. 312 - 322,

Journal articles | 2021

King C, 2021, 'Tfh cells set the stage for tumor control', Immunity, 54, pp. 2690 - 2692,

Journal articles | 2021

Sprent J; King C, 2021, 'COVID-19 vaccine side effects: The positives about feeling bad', Science Immunology, 6,

Journal articles | 2020

King C, 2020, 'CAR NK Cell Therapy for T Follicular Helper Cells', Cell Reports Medicine, 1, pp. 100009,

Journal articles | 2019

Cosorich I; McGuire HM; Warren J; Danta M; King C, 2019, 'CCR9 expressing T helper and T follicular helper cells exhibit site-specific identities during inflammatory disease', Frontiers in Immunology, 10, pp. 2899,

Journal articles | 2019

Lalwani A; Warren J; Liuwantara D; Hawthorne WJ; O'Connell PJ; Gonzalez FJ; Stokes RA; Chen J; Laybutt DR; Craig ME; Swarbrick MM; King C; Gunton JE, 2019, 'β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes', Cell Reports, 27, pp. 2370 - 2384.e6,

Journal articles | 2019

Zammit N; Siggs OM; Gray P; King C; Christ D; Goodnow CC; Grey S; Cowley M; Craig M; Dinger M; Ziegler J; Villanueva J; Cultrone D; Brink R, 2019, 'Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants', bioRxiv, pp. 589507,

Journal articles | 2019

Zammit NW; Siggs OM; Gray PE; Horikawa K; Langley DB; Walters SN; Daley SR; Loetsch C; Warren J; Yap JY; Cultrone D; Russell A; Malle EK; Villanueva JE; Cowley MJ; Gayevskiy V; Dinger ME; Brink R; Zahra D; Chaudhri G; Karupiah G; Whittle B; Roots C; Bertram E; Yamada M; Jeelall Y; Enders A; Clifton BE; Mabbitt PD; Jackson CJ; Watson SR; Jenne CN; Lanier LL; Wiltshire T; Spitzer MH; Nolan GP; Schmitz F; Aderem A; Porebski BT; Buckle AM; Abbott DW; Ziegler JB; Craig ME; Benitez-Aguirre P; Teo J; Tangye SG; King C; Wong M; Cox MP; Phung W; Tang J; Sandoval W; Wertz IE; Christ D; Goodnow CC; Grey ST, 2019, 'Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity', Nature Immunology, 20, pp. 1299 - 1310,

Journal articles | 2018

Wirasinha RC; Vijayan D; Smith NJ; Parnell GP; Swarbrick A; Brink R; King C; Stewart G; Booth DR; Batten M, 2018, 'GPR65 inhibits experimental autoimmune encephalomyelitis through CD4+ T cell independent mechanisms that include effects on iNKT cells', Immunology and Cell Biology, 96, pp. 128 - 136,

Journal articles | 2017

Corpuz TM; Vazquez-Lombardi R; Luong JK; Warren J; Stolp J; Christ D; King C; Brink R; Sprent J; Webster KE, 2017, 'IL-2 shapes the survival and plasticity of IL-17-producing γδ T Cells', Journal of Immunology, 199, pp. 2366 - 2376,

Journal articles | 2017

Jandl C; Liu SM; Cañete PF; Warren J; Hughes WE; Vogelzang A; Webster K; Craig ME; Uzel G; Dent A; Stepensky P; Keller B; Warnatz K; Sprent J; King C, 2017, 'IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2', Nature Communications, 8,

Journal articles | 2017

Jandl C; Loetsch C; King C, 2017, 'Cytokine expression by T follicular helper cells', , 1623, pp. 95 - 103,

Journal articles | 2017

Loetsch C; Warren J; Laskowski A; Vazquez-Lombardi R; Jandl C; Langley DB; Christ D; Thorburn DR; Ryugo DK; Sprent J; Batten M; King C, 2017, 'Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes', Cell Reports, 21, pp. 1624 - 1638,

Journal articles | 2017

Vazquez-Lombardi R; Loetsch C; Zinkl D; Jackson J; Schofield P; Deenick EK; King C; Phan TG; Webster KE; Sprent J; Christ D; Vazquez Lombardi R, 2017, 'Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells', Nature Communications, 8, pp. 15373,

Journal articles | 2016

Cho JH; Kim HO; Ju YJ; Kye YC; Lee GW; Lee SW; Yun CH; Bottini N; Webster K; Goodnow CC; Surh CD; King C; Sprent J, 2016, 'CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells', Nature Communications, 7, pp. 13373,

Journal articles | 2016

Jandl C; King C, 2016, 'Correction: Cytokines in the Germinal Center Niche Antibodies 2016, 5(1), 5', Antibodies, 5, pp. 10,

Journal articles | 2016

Jandl C; King C, 2016, 'Cytokines in the germinal center niche', Antibodies, 5, pp. 5,

Journal articles | 2016

vijayan D; redzwan M; avery DT; wirasinha RC; brink R; walters G; adelstein S; kobayashi M; gray P; elliott M; king C; vinuesa C; ghilardi N; ma CS; Tangye SG; batten M, 2016, 'IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice', Journal of Immunology, 197, pp. 3008 - 3017,

Journal articles | 2015

Foo SY; Zhang V; Lalwani A; Lynch JP; Zhuang A; Lam CE; Foster PS; King C; Steptoe RJ; Mazzone SB; Sly PD; Phipps S, 2015, 'Regulatory T cells prevent Inducible BALT formation by dampening neutrophilic inflammation', Journal of Immunology, 194, pp. 4567 - 4576,

Journal articles | 2015

McGuire HM; Vogelzang A; Warren J; Loetsch C; Natividad KD; Chan TD; Brink R; Batten M; King C, 2015, 'IL-21 and IL-4 collaborate to shape t-dependent antibody responses', Journal of Immunology, 195, pp. 5123 - 5135,

Journal articles | 2014

King C; McGuire H, 2014, 'The immunobiology of interleukin-21', Encyclopedia of Medical Immunology, 1

Journal articles | 2014

Tobias I; King C; Newton A, 2014, 'Mechanisms of atypical protein kinase C activation in insulin signaling (767.9)', The FASEB Journal, 28,

Journal articles | 2014

Vogelzang A; McGuire HM; Liu SM; Gloss B; Mercado K; Earls P; Dinger ME; Batten M; Sprent J; King C, 2014, 'IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells', Journal of Immunology, 192, pp. 1404 - 1414,

Journal articles | 2013

Liu SM; King C, 2013, 'IL-21-producing Th cells in immunity and autoimmunity', Journal of Immunology, 191, pp. 3501 - 3506,

Journal articles | 2013

Natividad KDT; Junankar S; Mohd redzwan N; Wirasinha RC; King C; Brink R; Swarbrick A; Batten ML; Nair R, 2013, 'Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors', PLoS ONE, 8, pp. e57469,

Journal articles | 2012

King C; Sprent J, 2012, 'Emerging cellular networks for regulation of T follicular helper cells', Trends in Immunology, 33, pp. 59 - 65,

Journal articles | 2011

Badami E; Sorini C; Coccia M; Usuelli V; Molteni L; Bolla AM; Scavini M; King C; Bosi E; Falcone M, 2011, 'Defective differentiation of regulatory FoxP3+ T cells by small-intestinal dendritic cells in patients with type 1 diabetes', Diabetes, 60, pp. 2120 - 2124,

Journal articles | 2011

King C; Sarvetnick N, 2011, 'The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions', PLoS One, 6, pp. e17049,

Journal articles | 2011

King C, 2011, 'A Fine Romance: T Follicular Helper Cells and B Cells', Immunity, 34, pp. 827 - 829,

Journal articles | 2011

McGuire HM; Vogelzang A; Ma CS; Hughes WE; Silveira PA; Tangye SG; Christ DU; Fulcher DA; Falcone M; King C, 2011, 'A subset of interleukin-21(+) chemokine receptor CCR9(+) T helper cells target accessory organs of the digestive system in autoimmunity', Immunity, 34, pp. 602 - 615,

Journal articles | 2011

McGuire HM; Walters SN; Vogelzang A; Lee CM; Webster KE; Sprent J; Christ DU; Grey S; King C, 2011, 'Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models', Diabetes, 60, pp. 867 - 875,

Journal articles | 2010

Lee CM; McGuire HM; Basten A; King C; Christ DU, 2010, 'Expression, purification and characterization of recombinant interleukin-21', Journal of Immunological Methods, 362, pp. 185 - 189,

Journal articles | 2009

King C, 2009, 'New insights into the differentiation and function of T follicular helper cells', Nature Reviews Immunology, 9, pp. 757 - 766,

Journal articles | 2009

McGuire HM; Vogelzang A; Hill N; Flodstrom-Tullberg M; Sprent J; King C, 2009, 'Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus', Proceedings of the National Academy of Sciences of the United States of America, 106, pp. 19438 - 19443,

Journal articles | 2009

Vogelzang A; McGuire H; Sprent J; King C, 2009, 'A fundamental role for Interleukin-21 in germinal center antibody responses', JOURNAL OF IMMUNOLOGY, 182,

Journal articles | 2009

Yu D; Batten ML; MacKay CR; King C, 2009, 'Lineage specification and heterogeneity of T follicular helper cells', Current Opinion in Immunology, 21, pp. 619 - 625,

Journal articles | 2008

Akerfeldt M; Howes J; Chan JY; Stevens VA; Boubenna N; McGuire HM; King C; Biden TJ; Laybutt DR, 2008, 'Cytokin-induced (beta)-cell death is independent of endoplasmic reticulum stress signalling', Diabetes, 57, pp. 3034 - 3044,

Journal articles | 2008

Hill NJ; King C; Flodstrom-Tullberg M, 2008, 'Recent acquisitions on the genetic basis of autoimmune disease', Frontiers in Bioscience, 13, pp. 4838 - 4851,

Journal articles | 2008

King C, 2008, 'T helper cell differentiation - IL-21 and T helper cell differentiation: Jack of all trades?', Immunology and Cell Biology, 86, pp. 554 - 556,

Journal articles | 2008

King CK; Tangye SG; MacKay CR, 2008, 'T follicular helper (T-FH) cells in normal and dysregulated immune responses', Annual Review of Immunology, 26, pp. 741 - 766,

Journal articles | 2008

Sonderegger I; Kisielow J; Meier R; King C; Kopf M, 2008, 'IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo', European Journal of Immunology, 38, pp. 1833 - 1838,

Journal articles | 2008

Vogelzang A; King C, 2008, 'The modulatory capacity of interleukin-21 in the pathogenesis of autoimmune disease', Frontiers in Bioscience, 13, pp. 5304 - 5315,

Journal articles | 2008

Vogelzang A; McGuire H; Yu D; Sprent J; MacKay CR; King CK, 2008, 'A fundamental role for interleukin-21 in the generation of T follicular helper cells', Immunity, 29, pp. 127 - 137

Journal articles | 2004

King C; Ilic A; Koelsch KK; Sarvetnick N, 2004, 'Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity', Cell, 117, pp. 265 - 277,

Journal articles | 2002

Cobb BR; Ruiz F; King CM; Fortenberry J; Greer H; Kovacs T; Sorscher EJ; Clancy JP, 2002, 'A₂ adenosine receptors regulate CFTR through PKA and PLA₂', AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 282, pp. L12 - L25,

Journal articles | 2001

Hayashi M; Tapping RI; Chao TH; Lo JF; King CC; Yang Y; Lee JD, 2001, 'BMK1 Mediates Growth Factor-induced Cell Proliferation through Direct Cellular Activation of Serum and Glucocorticoid-inducible Kinase', Journal of Biological Chemistry, 276, pp. 8631 - 8634,

Journal articles | 2001

King C; Mueller Hoenger R; Malo Cleary M; Murali-Krishna K; Ahmed R; King E; Sarvetnick N, 2001, 'Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses', Nature Medicine, 7, pp. 206 - 214,

Journal articles | 2000

King C, 2000, 'Potential consequences of interactions between aeroallergens and cells within the respiratory tree', Particle-Lung Interactions,

Journal articles | 1998

King C; Brennan S; Thompson PJ; Stewart GA, 1998, 'Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium', Journal of Immunology, 161, pp. 3645 - 3651,

Journal articles | 1998

King C; Davies J; Mueller R; Lee MS; Krahl T; Yeung B; O'Connor E; Sarvetnick N, 1998, 'TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype', Immunity, 8, pp. 601 - 613,

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