Associate Professor Laurence Wakelin

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Associate Professor Laurence Wakelin

Honorary Associate Professor

BSc.(Hons) 1st Class Chemistry, University of Kent, UK, 1971.

PhD Pharmacology, Clare College, University of Cambridge, UK, 1975.

Science

School of Chemistry

Education

University of Kent, United Kingdom, BSc(Hons) 1st Class Chemistry 1971.

University of Cambridge, United Kingdom, PhD Pharmacology 1975.

Employment

Department of Pharmacology, University of Cambridge, Science Research Council Fellow 1975-1977.

Department of Pharmacology, University of Cambridge, Medical Research Council Fellow, 1978-1980.

Senior Scientist, Peter MacCallum Cancer Institute, Melbourne, 1981-1989.

Professor of Cancer Research, University College Dublin, 1990-1997.

Visiting Fellow, School of Chemistry, ��Ʊ, 1998.

Associate Professor, School of Medical Sciences, ��Ʊ, 1999-2019.

Appointed Honorary Associate Professor, School of Chemistry, ��Ʊ, April 2019.

Mobile

+61414286217

E-mail

l.wakelin@unsw.edu.au

Location

School of Chemistry, Dalton Building, ��Ʊ Sydney, NSW 2052, Australia,

Book Chapters | 2011

Wolf S; Wakelin L; Catchpoole DR, 2011, 'Considerations for Treatment Development in Rhabdomyosarcoma: In Vitro Assessment of Novel DNA Binding Drugs', in Derbel F (ed.), Soft Tissue Tumors, edn. 1st, InTech, November, 2011, pp. 3 - 30

Book Chapters | 1991

Wakelin L, 1991, 'On creating targets in DNA designed to be 'hot-spots' for radiation damage.', in Seymour C; Mothersill C (ed.), New Developments in Fundamental and Applied Radiobiology, Taylor and Francis, London, pp. 269 - 274,

Book Chapters | 1991

Wickham G; Wakelin L; Palmer B; Lee H; Johnson P; Baguley BC; Denny WA; McFadyen DW, 1991, 'Cis-diammine platinum (II) complexes tethered to DNA-affinic ligands: antitumour activity and DNA-binding properties', in Howell SB (ed.), Proceedings of the Sixth International Symposium on Platinum and Other Metal Co-ordination Compounds in Cancer Chemotherapy, Plenum, New York, pp. 51 - 60,

Book Chapters | 1990

Wakelin L; Denny WA, 1990, 'Kinetic and equilibrium binding studies of a series of intercalating agents that bind by threading a sidechain through the DNA helix', in Pullman B; Jortner J (ed.), Molecular Basis of Specificity in Nucleic Acid-Drug Interactions, edn. JERUSALEM SYMPOSIA ON QUANTUM CHEMISTRY AND BIOCHEMISTRY, Kluwer Academic Publishers, Dordrecht, pp. 191 - 206,

Book Chapters | 1990

Wakelin L; Waring M, 1990, 'DNA intercalating agents', in Hansch C; Sammes PG; Taylor JB (ed.), Comprehensive Medicinal Chemistry, The Rational Design, Mechanistic Study, and Therapeutic Application of Chemical Compounds, edn. Volume 2, Pergamon Press, Oxford, UK, pp. 703 - 724

Book Chapters | 1988

Denny WA; Wakelin L, 1988, 'Tricyclic carboxamides: relationships between antitumour activity and geometry and kinetics of binding to DNA.', in Sarma RH; Sarma MH (ed.), Structure and Expression: DNA and Its Drug Complexes, edn. Volume 2, Adenine Press, USA, pp. 329 - 337
Journal articles | 2022

Chen J; Campbell AP; Wakelin LPG; Finch AM, 2022, 'Characterisation of bis(4-aminoquinoline)s as α1A adrenoceptor allosteric modulators', European Journal of Pharmacology, 916,

Journal articles | 2022

Constable GEO; Jung J; Read RW; Wakelin LPG; Bhadbhade MM; Hunter L, 2022, 'Synthesis of phenazine-2,8-dicarboxylates', ARKIVOC, pp. 46 - 57,

Journal articles | 2022

Zihlif M; Catchpoole DR; Stewart BW; Wakelin LPG, 2022, 'Withdrawn: Variations in Altered Global Gene Expression caused by Topoisomerase II Poisons Assessed with Reference to Differences in DNA Binding.', Curr Mol Pharmacol,

Journal articles | 2021

Rowell KN; Thomas DS; Ball GE; Wakelin LPG, 2021, 'Molecular dynamic simulations of diacridine binding to DNA: Indications that C6 diacridine can bisintercalate spanning two base pairs', Biopolymers, 112, pp. e23409,

Journal articles | 2020

Serobian A; Pracey CP; Thomas DS; Denny WA; Ball GE; Wakelin LPG, 2020, 'Structures and dynamics of DNA complexes of the desmethyl analog of the cytotoxin MLN944: Insights into activity when a methyl isn't futile', Journal of Molecular Recognition, 33,

Journal articles | 2017

Campbell AP; Wakelin LPG; Denny WA; Finch AM, 2017, 'Homobivalent conjugation increases the allosteric effect of 9-aminoacridine at the α1-adrenergic receptors', Molecular Pharmacology, 91, pp. 135 - 144,

Journal articles | 2014

Chen J; Campbell AP; Urmi KF; Wakelin LPG; Denny WA; Griffith R; Finch AM, 2014, 'Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines', Bioorganic and Medicinal Chemistry, 22, pp. 5910 - 5916,

Journal articles | 2014

Drwal MN; Marinello J; Manzo SG; Wakelin LPG; Capranico G; Griffith R, 2014, 'Novel DNA topoisomerase iia inhibitors from combined ligand- and structure- based virtual screening', Plos One, 9, pp. e114904,

Journal articles | 2014

Serobian A; Thomas DS; Ball GE; Denny WA; Wakelin LPG, 2014, 'The solution structure of bis(phenazine-1-carboxamide)-DNA complexes: MLN 944 binding corrected and extended', Biopolymers, 101, pp. 1099 - 1113,

Journal articles | 2013

Chen J; Murad AK; Wakelin L; Denny WA; Griffith R; Finch AM, 2013, 'a1-Adrenoceptor and serotonin 5-HT1A receptor affinity of homobivalent 4-aminoquinoline compounds: An investigation of the effect of linker length', Biochemical Pharmacology, 85, pp. 1534 - 1541,

Journal articles | 2011

Malgorzata ND; Agama K; Wakelin L; Pommier Y; Griffith R; Drwal M, 2011, 'Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents', PLoS One, 6, pp. 1 - 12,

Journal articles | 2011

Wolf S; Huynh T; Bryce NS; Hambley TW; Wakelin L; Stewart BW; Stewart D, 2011, 'Intracellular Trafficking as a Determinant of AS-DACA Cytotoxicity in Rhabdomyosarcoma Cells', BMC Cell Biology, 12, pp. 1 - 11,

Journal articles | 2010

He Z; Lai D; Wakelin L, 2010, '[Co(III)(cyclen)Cl2]Cl is selectively cytotoxic to human leukaemia cells', European Journal of Pharmacology, 637, pp. 11 - 15,

Journal articles | 2010

Zihlif M; Catchpoole DR; Stewart BW; Wakelin L, 2010, 'Effects of DNA minor groove binding agents on global gene expression', Cancer Genomics and Proteomics, 7, pp. 323 - 330

Journal articles | 2010

Zihlif MA; Wakelin LPG; Catchpoole D; Stewart B, 2010, 'Determining the mechanism of action of novel bisintercalating agents using the cDNA microarray technology', CANCER RESEARCH, 70,

Journal articles | 2009

Majid AA; Smythe GA; Denny WA; Wakelin L, 2009, 'Mass spectrometry studies of the binding of the minor groove-directed alkylating agent alkamin to AT-Tract Oligonucleotides', Chemical Research in Toxicology, 22, pp. 146 - 157

Journal articles | 2009

Wolf S; Wakelin L; He Z; Stewart BW; Catchpoole DR, 2009, 'In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines', Cancer Chemotherapy and Pharmacology, 64, pp. 1059 - 1069

Journal articles | 2009

Zihlif M; Catchpoole DR; Stewart BW; Wakelin L, 2009, 'Effects of DNA threading bis(9-aminoacridine-4-carboxamides) on global gene expression', Cancer Genomics and Proteomics, 6, pp. 317 - 323

Journal articles | 2008

He Z; Bu X; Eleftheriou A; Zihlif M; Qing Z; Stewart BW; Wakelin L, 2008, 'DNA threading bis(9-aminoacridine-4-carboxamides): Effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest', Bioorganic and Medicinal Chemistry, 16, pp. 4390 - 4400,

Journal articles | 2007

Majid A; Smythe GA; Denny WA; Wakelin L, 2007, 'Structure of the d( CGCGAATTCGCG)(2) complex of the minor groove binding alkylating agent alkamin studied by mass spectrometry', Molecular Pharmacology, 71, pp. 1165 - 1178

Journal articles | 2007

Majid A; Smythe GA; Denny WA; Wakelin L, 2007, 'Structure of the d(CGCGAATTCGCG)(2) complex of the minor groove binding alkylating agent alkamin studied by mass spectrometry (vol 71, pg 1165, 2007)', Molecular Pharmacology, 72, pp. 485 - 485

Journal articles | 2005

Edwards GL; Black DS; Deacon G; Wakelin L, 2005, 'Effect of charge and surface area on the cytotoxicity of cationic metallointercalation reagents', Canadian Journal of Chemistry - Revue Canadienne de Chimie, 83, pp. 969 - 979

Journal articles | 2005

Edwards GL; Black DS; Deacon G; Wakelin L, 2005, 'In vitro and in vivo studies of neutral cyclometallated complexes against murine leukaemias', Canadian Journal of Chemistry - Revue Canadienne de Chimie, 83, pp. 980 - 989

Journal articles | 2004

Adams A; Guss JM; Denny WA; Wakelin L, 2004, 'Structure of 9-amino-[N-(2-dimethylamino)propyl]acridine-4-carboxamidebound to d(CGTACG)(2): a comparison of structures of d(CGTACG)(2)complexed with intercalators in the presence of cobalt', ACTA Crystallographica Section D - Biological Crystallography, 60, pp. 823 - 828

Journal articles | 2004

Zihlif Z; Catchpoole D; He Z; Wakelin LPG; Stewart BW, 2004, '541 Effects of bisintercalating DNA threading agents on global gene expression', European Journal of Cancer Supplements, 2, pp. 165 - 165,

Journal articles | 2003

Baguley BC; Wakelin L; Jacintho J; Kovacic P, 2003, 'Mechanisms of action of DNA intercalating acridine-based drugs: Howimportant are contributions from electron transfer and oxidative stress?', Current Medicinal Chemistry: Cardiovascular and Hematological Agents, 10, pp. 2643 - 2649

Journal articles | 2003

Howarth N; Wakelin L; Walker D, 2003, 'Synthesis of the four diastereoisomers of 3-thymine-1-(tbutoxycarbonyl)amino-cyclopentane-1-carboxylic acid.', Tetrahedron Letters, 44, pp. 695 - 698

Journal articles | 2003

Howarth N; Wakelin L; Walker D, 2003, 'alpha-cycloPNA: 1-aminocyclopentane-1-carboxylic acid-derived peptide nucleic acids.', Nucleosides, Nucleotides and Nucleic Acids, 22, pp. 1351 - 1353,

Journal articles | 2003

Wakelin L; Bu X; Eleftheriou A; Parmar A; Hayek CB; Stewart BW, 2003, 'Bisintercalating threading diacridines: Relationships between DNAbinding, cytotoxicity, and cell cycle arrest', Journal of Medicinal Chemistry, 46, pp. 5790 - 5802

Journal articles | 2002

Adams A; Guss JM; Denny WA; Wakelin L, 2002, 'Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecrboxamide bound to d (CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons', Nucleic Acids Research, 30, pp. 719 - 725

Journal articles | 2002

Teixeira SC; Thorpe JH; Todd AK; Powell HK; Adams A; Wakelin L; Denny WA; Cardin CJ, 2002, 'Structural Characterisation of Bisintercalation in Higher-order DNA at a Junction-like Quadruplex', Journal of Molecular Biology, 323, pp. 167 - 171

Journal articles | 2002

Wakelin L; Adams A; Denny WA, 2002, 'Kinetic Studies of the Binding of Acridinecarboxamide Topoisomerase Poisons to DNA: Implications for Mode of Binding of Ligands with Unchanged Chromophores', Journal of Medicinal Chemistry, 45, pp. 894 - 901

Journal articles | 2001

Kovacic P; Wakelin L, 2001, 'DNA molecular electrostatic potential: novel perspectives for the mechanism of action of anticancer drugs involving electron transfer and oxidative stress', Anti-Cancer Drug Design, 16, pp. 175 - 184

Journal articles | 2000

Adams A; Guss M; Collyer C; Denny WA; Prakash AS; Wakelin L, 2000, 'Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 0-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides', Molecular Pharmacology, 58, pp. 649 - 658

Journal articles | 2000

Adams A; Guss M; Collyer C; Denny WA; Wakelin L, 2000, 'A novel form of intercalation involving four DNA duplexes in an acridine-4-carboxamide complex of d(CGTACG)2', Nucleic Acids Research, 28, pp. 4244 - 4253

Journal articles | 2000

Howarth NM; Wakelin LPG, 2000, 'alpha-PNA: A novel peptide nucleic acid analogue of DNA (vol 62, pg 5442, 1997)', JOURNAL OF ORGANIC CHEMISTRY, 65, pp. 634 - 634,

Journal articles | 1999

Adams A; Collyer C; Guss M; Denny WA; Wakelin L, 1999, 'Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2', Biochemistry, 38, pp. 9221 - 9233

Journal articles | 1999

McClean S; Costelloe C; Denny WA; Searcy M; Wakelin L, 1999, 'Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards', Anti-Cancer Drug Design, 14, pp. 187 - 204

Journal articles | 1999

Todd AV; Adams A; Powell HK; Wilcock DJ; Thorpe JH; Lausi A; Zanini F; Wakelin L; Cardin CJ, 1999, 'Determination of MAD-DM of the structure of the DNA duplex d(ACGTACG(5-BrU)2 at 1.4 A and 100 K', ACTA Crystallographica Section D - Biological Crystallography, 55, pp. 729 - 735

Journal articles | 1999

Todd AV; Adams A; Thorpe J; Denny WA; Wakelin L; Cardin CJ, 1999, 'Major groove binding and a `DNA-induced` fit in the intercalation of a derivative of the mixed topoisomerase I/II inhibitor (N-(2-dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU', Journal of Medicinal Chemistry, 42, pp. 536 - 540

Journal articles | 1998

Hendersen ; Lacey S; O'Hare C; Hartley J; McClean S; Wakelin L; Kelland L; Robbins D, 1998, 'Synthesis of new bifunctional compounds which selectively alkylate guanines in DNA.', Anti-Cancer Drug Design, 13, pp. 749 - 768

Journal articles | 1998

Searcy M; McClean S; Madden B; McGowan A; Wakelin L, 1998, 'Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives.', Anti-Cancer Drug Design, 13, pp. 837 - 855

Journal articles | 1998

Whittaker JK; Mcfadyen DW; Wickham G; Wakelin L; Murray VM, 1998, 'The interaction of DNA-targeted platinum phenanthridinium complexes with DNA', Nucleic Acids Research, 26, pp. 3933 - 3939

Journal articles | 1997

Howarth N; Wakelin L, 1997, 'Alpha-PNA: A novel peptide nucleic acid analogue of DNA.', Journal Organic Chemistry, 62, pp. 5441 - 5450

Journal articles | 1997

Searcy M; McClean S; Madden B; Wakelin L, 1997, 'Bleomycin mimics. Design and synthesis of an acridine derivative which cleaves DNA in a sequence-neutral manner.', Journal of the Chemical Society, Perkin Transactions 2, pp. 523 - 532

Journal articles | 1996

Searcy M; Martin PN; Howarth N; Madden B; Wakelin L, 1996, 'DNA threading agents: Effect of sidechain bulk on DNA binding and cytotoxicity of 9-anilinoacridine-4-carboxamides.', Bioorganic and Medicinal Chemistry Letters, 6, pp. 1831 - 1836

Journal articles | 1996

Wilcock DJ; Adams A; Cardin CJ; Wakelin L, 1996, 'Crystal and molecular structure of the DNA octanucleotide d(ACGTACGT)2.', Acta Crystallographica D, 52, pp. 481 - 485

Journal articles | 1992

Bailly C; Denny WA; Mellor E; Wakelin L; Waring M, 1992, 'Sequence specificity of the binding of antitumour amsacrine-4-carboxamides to DNA studied by DNase I footprinting.', Biochemistry, 31, pp. 3514 - 3524

Journal articles | 1992

Deacon G; Webster L; Buxton D; Hillcoat B; James A; Roos I; Thomson R; Wakelin L; Williams T, 1992, 'Cis-Dipyridineplatinum(II) organoamides with unexpected growth inhibition properties and antitumour activity.', Journal Medicinal Chemistry, 35, pp. 3349 - 3353

Journal articles | 1992

Lee H; Palmer B; Baguley BC; Mcfadyen DW; Wickham G; Thorsborn-Palmer D; Wakelin L; Denny WA, 1992, 'DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of cis-ethane-1,2-diamminodichloro-platinum (II).', Journal Medicinal Chemistry, 35, pp. 2983 - 2987

Journal articles | 1992

Palmer B; Wickham G; McFadyen DW; Craik D; Wakelin L; Baguley BC; Denny WA, 1992, 'Synthesis, DNA binding interactions and biological activity of bis platinum (II) complexes of N,N,N',N'-tetrakis(2-aminoethyl)-diamines.', Anti-Cancer Drug Design, 7, pp. 385 - 401

Journal articles | 1992

Webster LK; Hillcoat BL; Roos IAG; Wakelin LPG; Deacon GB; Buxton DP; James AM; Thomson RJ; Williams TL, 1992, 'Cis-Bis(pyridine)platinum(II) Organoamides with Unexpected Growth Inhibition Properties and Antitumor Activity', Journal of Medicinal Chemistry, 35, pp. 3349 - 3353,

Journal articles | 1991

Gourdie T; Prakash AS; Wakelin L; Woodgate P; Denny WA, 1991, 'Synthesis and evaluation of DNA-targeted spatially-separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability', Journal Medicinal Chemistry, 34, pp. 240 - 248

Journal articles | 1991

Plummer S; Parker N; De Kretser T; Wakelin L, 1991, 'Selective inhibition of c-myc and c-myb transcription by antitumour anthracyclines in human tumour cells.', Journal of Cellular Pharmacology, 2, pp. 248 - 256

Journal articles | 1991

Prakash AS; Valu K; Wakelin L; Woodgate P; Denny WA, 1991, 'Synthesis and antitumour activity of the spatially-separated mustard bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5-((N,N-dimethylamino)-methyl)aminophenyl]-1,4-benzenedicarboxamide, which alkylates DNA exclusively at adenines in the minor groove.', Anti-Cancer Drug Design, 6, pp. 195 - 206

Journal articles | 1991

Searle M; Bicknell W; Wakelin L; Denny WA, 1991, 'Anthracycline antibiotic arugomycin binds in both grooves of the DNA helix simultaneously: an NMR and molecular modelling study.', Nucleic Acids Research, 19, pp. 2897 - 2906

Journal articles | 1991

Wickham G; Prakash AS; Wakelin L; McFadyen DW, 1991, 'DNA-binding properties and antitumour activity of monofunctional alkylating groups attached to the DNA-intercalating chromophore phenanthridine: n-bromo-alkylphenanthridinium bromides.', Biochimica Biophysica Acta, 1073, pp. 528 - 537

Journal articles | 1990

Bray A; Kelly D; Mack P; Martin R; Wakelin L, 1990, 'Synthesis of a peptide-linked binuclear platinum (II) terpyridine complex', Australian Journal Chemistry, 43, pp. 629 - 634

Journal articles | 1990

Bray AM; Kelly DP; Mack OLP; Martin RF; Wakelin LPG, 1990, 'DNA-Binding Compounds. III. Synthesis of a Peptide-Linked Binuclear Platinum(II)-Terpyridine Complex', Australian Journal of Chemistry, 43, pp. 629 - 634,

Journal articles | 1990

Denny WA; Wakelin L, 1990, 'Kinetics of the binding of mitoxantrone, ametantrone and analogues to DNA: relationship to binding mode and antitumour activity.', Anti-Cancer Drug Design, 5, pp. 189 - 200

Journal articles | 1990

Gourdie T; Valu K; Gravatt G; Boritzki T; Baguley BC; Wakelin L; Wilson W; Woodgate P; Denny WA, 1990, 'DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard', Journal Medicinal Chemistry, 33, pp. 1177 - 1186

Journal articles | 1990

McFadyen DW; Sotirellis N; Denny WA; Wakelin L, 1990, 'Interaction of substituted and rigidly-linked diquinolines with DNA.', Biochimica Biophysica Acta, 1048, pp. 50 - 58

Journal articles | 1990

Palmer B; Lee H; Johnson P; Baguley BC; Wickham G; Wakelin L; McFadyen DW; Denny WA, 1990, 'DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine.', Journal Medicinal Chemistry, 33, pp. 3008 - 3014

Journal articles | 1990

Prakash AS; Denny WA; Gourdie T; Valu K; Woodgate P; Wakelin L, 1990, 'DNA-directed alkylating ligands as potential antitumour agents: sequence specificity of alkylation by intercalating aniline mustards', Biochemistry, 29, pp. 9799 - 9807

Journal articles | 1990

Prakash AS; Denny WA; Wakelin L, 1990, 'Differences in sequence selectivity of DNA alkylation by isomeric intercalating aniline mustards.', Chemistry-Biology Interactions, 76, pp. 241 - 248

Journal articles | 1990

Roberts A; Denny WA; Wakelin L; Anderson B; Wilson W, 1990, 'Radio-sensitisation of mammalian cells in vitro by nitroacridines', Radiation Research, 123, pp. 153 - 164

Journal articles | 1990

Searle M; Wakelin L, 1990, 'Conformation and dynamics of the deoxyribose rings in the (nogalamycin)2/d(GCATGC)2 complex studied in solution by 1H NMR spectroscopy.', Biochemical Journal, 269, pp. 341 - 346

Journal articles | 1990

Searle M; Wakelin L, 1990, 'Sequence-specific conformation of a DNA decamer containing an adenine tract studied in solution by 1H NMR spectroscopy.', Biochimica Biophysica Acta, 1049, pp. 69 - 77

Journal articles | 1990

Valu K; Gourdie T; Boritzki T; Gravatt G; Baguley BC; Wilson W; Wakelin L; Woodgate P; Denny WA, 1990, 'DNA-directed alkylating agents. 3. Structure activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain.', Journal Medicinal Chemistry, 33, pp. 3014 - 3019

Journal articles | 1990

Wakelin L; Chetcuti P; Denny WA, 1990, 'Kinetic and equilibrium studies of amsacrine-4-carboxamides: a class of asymmetrical DNA intercalating agent which must bind by threading through the DNA helix.', Journal Medicinal Chemistry, 33, pp. 2039 - 2044

Journal articles | 1989

Searle M; Hall J; Denny WA; Wakelin L, 1989, 'Interaction of the antitumour antibiotic luzopeptin with the hexanucleotide d(5'-GCATGC)2: one and two-dimensional NMR studies.', Biochemical Journal, 259, pp. 433 - 441

Journal articles | 1989

Searle M; Hall J; Kyratsis L; Wakelin L, 1989, 'Didemnin B: conformation and dynamics of an antitumour and antiviral depsipeptide studied in solution by 1H and 13C NMR.', International Journal of Peptide and Protein Research, 34, pp. 445 - 454

Journal articles | 1988

Mcfadyen DW; Denny WA; Wakelin L, 1988, 'Alkyl-linked diquinolines are monofunctional AT-selective DNA intercalating agents.', FEBS Letters, 228, pp. 235 - 240

Journal articles | 1988

Searle M; Hall J; Denny WA; Wakelin L, 1988, 'NMR studies of the interaction of the antibiotic nogalamycin with the hexadeoxyribonucleotide duplex d(5'-GCATGC)2.', Biochemistry, 27, pp. 4340 - 4349

Journal articles | 1988

Searle M; Hall J; Wakelin L, 1988, '1H and 13C NMR studies of the antitumour antibiotic luzopeptin: resonance assignments, conformation and flexibility in solution.', Biochemical Journal, 256, pp. 271 - 278

Journal articles | 1987

Brownlee R; McFadyen DW; O'Connor M; Rook T; Roos I; Wakelin L, 1987, 'An NMR study of substituent effects in platinum (II) intercalating agents.', Magnetic Resonance in Chemistry, 25, pp. 492 - 496

Journal articles | 1987

Denny WA; Wakelin L, 1987, 'Mode and kinetics of DNA binding of the antitumour agent bisantrene.', Anti-Cancer Drug Design, 2, pp. 71 - 77

Journal articles | 1987

Mack P; Kelly D; Martin R; Wakelin L, 1987, 'DNA-binding compounds. II. Synthesis of a peptide-linked triacridine.', Australian Journal of Chemistry, 40, pp. 97 - 105

Journal articles | 1987

Mcfadyen DW; Wakelin L; Roos I; Hillcoat B, 1987, 'Binding of dimeric platinum (II) terpyridine complexes to DNA.', Biochemical Journal, 242, pp. 177 - 183

Journal articles | 1987

Wakelin L; Atwel G; Rewcastle ; Denny WA, 1987, 'Relationships between DNA binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumour agent.', Journal Medicinal Chemistry, 30, pp. 855 - 861

Journal articles | 1986

Adams A; Jarrott B; Denny WA; Wakelin L, 1986, 'Differences between central and peripheral alpha-adrenoceptors revealed using binuclear ligands.', European Journal of Pharmacology, 127, pp. 27 - 35

Journal articles | 1986

Denny WA; Roos I; Wakelin L, 1986, 'Inter-relationships between antitumour activity, DNA breakage and DNA binding kinetics for 9-aminoacridinecarboxamide antitumour agents.', Anti-Cancer Drug Design, 1, pp. 141 - 146

Journal articles | 1986

Denny WA; Wakelin L, 1986, 'Kinetic and equilibrium studies of the interaction of amsacrine and anilino-ring substituted analogues with DNA.', Cancer Research, 46, pp. 1717 - 1721

Journal articles | 1986

Mcfadyen DW; Wakelin L; Roos I; Hillcoat B, 1986, 'Binuclear platinum (II) terpyridine complexes: a new class of bifunctional DNA intercalating agent.', Biochemical Journal, 238, pp. 757 - 763

Journal articles | 1986

Wakelin L, 1986, 'Polyfunctional DNA intercalating agents.', Medicinal Research Reviews, 6, pp. 275 - 340

Journal articles | 1985

Adams A; Jarrott B; Elmes B; Denny WA; Wakelin L, 1985, 'Interaction of DNA-intercalating antitumour agents with adrenoceptors.', Molecular Pharmacology, 27, pp. 480 - 492

Journal articles | 1985

Denny WA; Atwel G; Baguley BC; Wakelin L, 1985, 'Potential antitumour agents. Part 44. Synthesis and antitumour activity of new classes of diacridines: the importance of linker chain rigidity for DNA-binding kinetics and antitumour activity.', Journal Medicinal Chemistry, 28, pp. 1568 - 1574

Journal articles | 1985

Denny WA; Atwel G; Willmott ; Wakelin L, 1985, 'Interaction of paired homologous series of diacridines and triacridines with deoxyribonucleic acid.', Journal of Biophysical Chemistry, 22, pp. 17 - 26

Journal articles | 1985

KELLY DP; MACK PO; MARTIN RF; WAKELIN LPG, 1985, 'DNA‐binding compounds – synthesis and intercalating properties of a peptide‐diamino diacridine', International Journal of Peptide and Protein Research, 26, pp. 400 - 406,

Journal articles | 1985

Kelly D; Mack P; Martin R; Wakelin L, 1985, 'A linear peptide as linker chain in polyfunctional DNA-binding agents. Synthesis of a peptide diamino bisacridine.', International Journal of Peptide and Protein Research, 26, pp. 400 - 406

Journal articles | 1985

Mcfadyen DW; Wakelin L; Roos I; Leopold V, 1985, 'Activity of platinum (II) intercalating agents against murine leukaemia L1210.', Journal Medicinal Chemistry, 28, pp. 1113 - 1116

Journal articles | 1985

Roos I; Wakelin L; Hakkennes J; Coles J, 1985, 'Collection and analysis of kinetic data from a stopped-flow spectrophotometer using a microcomputer.', Analytical Biochemistry, 146, pp. 287 - 298

Journal articles | 1985

Roos I; Wakelin L; Henry S, 1985, 'Intracellular DNA damage produced by a series of diacridines.', Biochemical Journal, 226, pp. 175 - 182

Journal articles | 1984

Wakelin L; McFadyen DW; Walpole A; Roos I, 1984, 'Interaction of phenylthiolato (2,2',2''-terpyridine) platinum (II) cation with DNA.', Biochemical Journal, 222, pp. 203 - 215

Journal articles | 1982

Kobylecki R; Lane A; Smith C; Wakelin L; Cruze W; Egert E; Kennard O, 1982, 'N-methyl nalorphine: definition of N-allyl conformation for antagonism of the opiate receptor.', Journal of Medicinal Chemistry, 25, pp. 1278 - 1280,

Journal articles | 1981

Fox K; Wakelin L; Waring M, 1981, 'Kinetics of the interaction between echinomycin and DNA.', Biochemistry, 20, pp. 5768 - 5779

Journal articles | 1981

Fox KR; Wakelin LPG; Waring MJ, 1981, 'Kinetics of the Interaction between Echinomycin and Deoxyribonucleic Acid', Biochemistry, 20, pp. 5768 - 5779,

Journal articles | 1981

Viswamitra M; Kennard O; Cruze W; Egert E; Sheldrick G; Jones P; Waring M; Wakelin L; Olsen F, 1981, 'The structure of the quinoxaline antibiotic analogue TANDEM and its relevance to the mechanism of bifunctional intercalation.', Nature, 289, pp. 817 - 819

Journal articles | 1981

Viswamitra MA; Kennard O; Cruse WBT; Egert E; Sheldrick GM; Jones PG; Waring MJ; Wakelin LPG; Olsen RK, 1981, 'Structure of TANDEM and its implication for bifunctional intercalation into DNA', Nature, 289, pp. 817 - 819,

Journal articles | 1981

Wakelin L; Hunter C; Adams A; Waring M, 1981, 'Interaction of crystal violet with nucleic acids.', Biochemistry, 20, pp. 5779 - 5787

Journal articles | 1981

Wilson W; Baguley BC; Wakelin L; Waring M, 1981, 'Interaction of the antitumour drug m-AMSA and related acridines with nucleic acids.', Molecular Pharmacology, 20, pp. 404 - 414

Journal articles | 1981

Wilson WR; Baguley BC; Wakelin LPG; Waring MJ, 1981, 'Interaction of the antitumor drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines with nucleic acids', Molecular Pharmacology, 20, pp. 404 - 414

Journal articles | 1980

Dean P; Wakelin L, 1980, 'Electrostatic components of drug-receptor recognition: I. Structural and sequence analogues of DNA polynucleotides.', Proceedings of the Royal Society, B, 209, pp. 453 - 471

Journal articles | 1980

Dean P; Wakelin L, 1980, 'Electrostatic components of drug-receptor recognition: II. The DNA-binding antibiotic actinomycin.', Proceedings of the Royal Society, B, 209, pp. 473 - 489

Journal articles | 1980

Wakelin L; Waring M, 1980, 'Kinetics of drug-DNA interaction: dependence of the binding mechanism on structure of the ligand.', Journal of Molecular Biology, 144, pp. 183 - 214

Journal articles | 1980

Wright RGMR; Wakelin LPG; Fieldes A; Acheson RM; Waring MJ, 1980, 'Effects of Ring Substituents and Linker Chains on the Bifunctional Intercalation of Diacridines into Deoxyribonucleic Acid', Biochemistry, 19, pp. 5825 - 5836,

Journal articles | 1979

Dean P; Wakelin L, 1979, 'The docking manoeuvre at a drug receptor: a quantum mechanical study of intercalative attack of ethidium and its carboxylated derivative on a DNA fragment.', Philosphical Transactions of the Royal Society, B, 287, pp. 571 - 607

Journal articles | 1979

Wakelin L; Creasy T; Waring M, 1979, 'The binding of an homologous series of diacridines to DNA.', FEBS Letters, 104, pp. 261

Journal articles | 1978

Balcarova Z; KleinwÃ chter V; Koudelka J; Lober G; Reinert K; Wakelin L; Waring M, 1978, 'Interaction of phenosafranine with nucleic acids and model polyphosphates. II. Characterisation of phenosafranine binding to double helical DNAs.', Biophysical Chemistry, 8, pp. 27 - 40

Journal articles | 1978

Balcarová Z; Kleinwächter V; Koudelka J; Klarner R; Löber G, 1978, 'Interaction of phencsafranine with nucleic acids and model polyphosphates. I. Self-aggregation and complex formation with inorganic polyphosphates', Biophysical Chemistry, 8, pp. 17 - 25,

Journal articles | 1978

Kleinwachter V; Balcarova Z; Koudelka J; Lober G; Reinert K; Wakelin L; Waring M, 1978, 'Characterisation of different modes of phenosafranine binding to double helical DNAs.', Studia Biophysica, 67, pp. S53 - S54,

Journal articles | 1978

Wakelin L; Romanos M; Chen T; Glaubiger D; Canellakis E; Waring M, 1978, 'Structural limitations on the bifunctional intercalation of diacridines into DNA.', Biochemistry, 17, pp. 5057 - 5063

Journal articles | 1976

Balcarova Z; Kleinwächter V; Waring M; Wakelin L; Lober G, 1976, 'Properties of phenosafranine complexes with deoxyribonucleic acids.', Studia Biophysica, 60, pp. 119 - 124

Journal articles | 1976

Wakelin L; Romanos M; Canellakis E; Waring M, 1976, 'Diacridines as bifunctional DNA-intercalating agents.', Studia Biophysica, 60, pp. 111 - 118

Journal articles | 1976

Wakelin L; Waring M, 1976, 'The binding of echinomycin to DNA.', Biochemical Journal, 157, pp. 721 - 740

Journal articles | 1975

Waring M; Wakelin L; Lee J, 1975, 'A solvent partition method for measuring the binding of drugs to DNA: application to the quinoxaline antibiotics echinomycin and triostin A.', BIOCHIMICA ET BIOPHYSICA ACTA, 407, pp. 200 - 212

Journal articles | 1974

Wakelin L; Waring M, 1974, 'The unwinding of circular deoxyribonucleic acid by phenanthridinium drugs: structure-activity relations for the intercalation reaction.', Molecular Pharmacology, 10, pp. 544 - 561

Journal articles | 1974

Wakelin L, 1974, 'Interaction of platinum II compounds with circular DNA.', Biochemical Society Transactions, 2, pp. 866 - 868,

Journal articles | 1974

Waring M; Wakelin L, 1974, 'Echinomycin: a bifunctional intercalating antibiotic.', Nature, 252, pp. 653 - 657,

Journal articles | 1971

Wall K; Wakelin L, 1971, 'Measurement of the rate of anion exchange and the effect of organic fouling.', Journal of Applied Chemistry and Biotechnology, 21, pp. 1 - 4
Conference Papers | 2017

Pracey CP; Serobian A; Thomas DS; Ball GE; Wakelin LP, 2017, 'Solution structure of the Mitoxantrone-DNA complex: A NMR and molecular modelling study', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, SCOTLAND, British Biophys Soc, Edinburgh, pp. S228 - S228, presented at 19th IUPAB Congress / 11th EBSA Congress, SCOTLAND, British Biophys Soc, Edinburgh, 16 July 2017 - 20 July 2017,

Conference Papers | 2010

Zihlif M; Wakelin L; Catchpool D; Stewart BBW, 2010, 'Insights into the cellular responses against different DNA-binding agents', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, GERMANY, Berlin, pp. 105 - 105, presented at 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, GERMANY, Berlin, 16 November 2010 - 19 November 2010,

Conference Papers | 2008

Freewan M; Denny WA; Wakelin L, 2008, 'Poisoning of human topoisomerase II alpha by acridinecarboxamides and related cytotoxins', in EJC Supplements, Pergamon-Elsevier Science Ltd, Kidlington, Oxford, England, pp. 28 - 28, presented at 20th Meeting of the European Association for Cancer Research, Lyon, FRANCE, 05 July 2008 - 08 July 2008,

Conference Papers | 2008

Khazaly AN; He Z; Stewart BW; Edwards GL; Wakelin L, 2008, 'Bisintercalating threading agents as cytotoxic inhibitors of transcription', in EJC Supplements, Pergamon-Elsevier Science Ltd, Kidlington, Oxford, England, pp. 83 - 84, presented at 20th Meeting of the European Association for Cancer Research, Lyon, FRANCE, 05 July 2008 - 08 July 2008

Conference Papers | 2006

Edwards GL; Black DS; Deacon G; Wakelin L, 2006, 'Cycometallated platinum and palladium complexes as anticancer agents: Everything old is new again', in Australia and New Zealand Symposium on Organometallic Chemistry OZOM3, Monash university, Gippsland, Australia, pp. 47 - 47, presented at 3rd Australian and New Zealand Symposium on Oranometallic Chemistry, Monash university, Gippsland, Australia, 08 January 2006 - 11 January 2006

Conference Papers | 2005

Peters FB; Serobian A; Ball GE; Denny WA; Wakelin L, 2005, 'DNA Intercalation by bix(phenazinecarboxamides): Structural Insights Into Anticancer Activity', in Apte S; Kable S; Baker AT (eds.), Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, pp. M017 PO Bi - -, presented at Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, 03 July 2005 - 07 July 2005

Conference Papers | 2005

Tam R; Suzuki M; Denny WA; Dawes I; Wakelin L, 2005, 'Mutations within the alpha4 helix of human DNA topoisomerase IIalpha confer differential sensitivities to topoisomerase poisons.', in Proceedings of the American Association for Cancer Research vol 46, American Association for Cancer Research, Philadelphia, USA, pp. 2401 - 2401, presented at 96th AACR Annual Meeting, Anaheim, USA, -

Conference Papers | 2003

Catchpoole DR; Guo D; Stewart BW; Eleftheriou A; Wakelin L, 2003, 'Effects of bisintercalating DNA threading agents on transcription in human leukemic CCRF-CEM cells studied by microarray analysis', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MASSACHUSETTS, BOSTON, pp. 6082S - 6082S, presented at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, MASSACHUSETTS, BOSTON, 17 November 2003 - 21 November 2003,

Conference Papers | 2002

Adams A; Guss JM; Denny WA; Wakelin LP, 2002, 'CRYSTAL STRUCTURES OF ACRIDINE-4-CARBOXAMIDES COMPLEXED WITH THE DNA HEXANUCLEOTIDE d(CGTACG)2', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C55 - C55,

Conference Papers | 2001

Adams A; Guss M; Denny WA; Wakelin L, 2001, 'Crystal structure of 9-amino[N-(2-morpholino)ethyl]acridine-4-carboxamide bound to d(CGTACG)2: A DNA complex of a biologically inactive derivative of the acridinecarboxamide topoisomerase poisons.', in Clinical Cancer Research vol 7, AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA, Birmingham, USA., pp. 3798S - 3798S, presented at AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics., Florida, USA.,

Conference Papers | 2001

Majid AA; Fonseka T; Smythe GA; Shiel M; Denny WA; Wakelin L, 2001, 'Characterisation of the DNA complex of an antitumour-active bifunctional polybenzamide alkylating agent using electrospray and MALDI-TOF mass spectrometry.', in Clinical Cancer Research vol 7, AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA, Birmingham, USA., pp. 3796S - 3796S, presented at AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics., Florida, USA,

Conference Papers | 2000

Adams A; Guss M; Collyer C; Prakash AS; Denny WA; Wakelin L, 2000, 'Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)-acridine-4-carboxamides.', in Clinical Cancer Research vol 6, AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA, Birmingham, USA, pp. 4531S - 4531S, presented at 11th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy., Amsterdam, Holland.

Conference Papers |

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