国民彩票

Associate Professor Matthew Baker

Associate Professor Matthew Baker

Associate Professor

DPhil, Oxford University.

BSc (Hons), Australian National University.

Science
School of Biotech & Biomolecular Science

Dr Matt Baker is a Scientia Associate Professor in the School of Biotechnology and Biomolecular Sciences at the University of New South Wales.

Matt completed his DPhil in Physics at Oxford University as a John Monash Scholar studying the bacterial flagellar motor that makes nearly all bacteria swim. Subsequently Matt investigated protein transport in Oxford's Chemistry Research Laboratory and in the Department of Biochemistry. Upon his return to Australia, Matt focused primarily on how simple subunit interactions govern assembly of complex architectures, including the rotor () and filament () of the bacterial flagellar motor. The next question is how this complexity emerged. To begin addressing this, Matt's nascent group at 国民彩票 looks at how ion selectivity changes using directed evolution (, ) to examine the evolutionary landscape that constrains the adaptation of the motor (). We then use this knowledge to examine potential applications of the flagellar motor elsewhere (, ).

Our group also investigates that in synthetic lipid bilayers (). These are essential at all scales of life, in bacteria to respond to osmotic shock and in mammals in the sense of touch and hearing and are involved in cancer progression and arthritis. In collaboration with , we probe membrane dynamics and interactions using novel DNA nanotechnology (Nanoscale 2019, ), with the ultimate goal to control membrane communication using de novo DNA nanotechnology.

Matt also has a love of radio: he was a Top 5 Under 40 Scientist in Residence at the ABC in 2015 and has continued since then as听the听regular science presenter on , broadcast on ABC Local across Australia, and by producing听content for the , , Saturday Extra and on ABC's Radio National. He is currently a 'Resident Scientist' on - Sydney's First Nations Radio station and also on 's flagship weekend breakfast show with Kim Hill. He also has applied his data skills to journalism; he was Australia's inaugural in 2016 when he was embedded at the Sydney Morning Herald. Matt is active in Australia-China relations and has been an delegate and panel chair at the since 2015.

Currently our group consists of 5 PhD students, 4 postdocs and 2 Hons students working in roughly a fifty-fifty split across flagellar and in vitro lipid/DNA projects. At any stage we welcome applications for PhDs and Hons students. We have recently by the , so applicants interested in postdoctoral opportunities should get in touch.

A collection of links can be found on Matt's .

Matt teaches in the School of Biotechnology and Biomolecular Science. He is co-convener of 3rd Year synthetic biology (BABS3200) focusing on DNA nanotechnology and directed evolution approaches, and he gives guest lectures into 1st Year Genes, 2nd Year Microbiology, 3rd Year Environmental Microbiology and 3rd Year Microbial Genetics.

Location
D26 L3 Room 301A
  • Book Chapters | 2019
    Cranfield CG; Kloda A; Nikolaev YA; Martinac AD; Ridone P; Bavi N; Bavi O; Petrov E; Battle AR; Nomura T; Rohde PR; Nakayama Y; Rosholm KR; Cox CD; Baker MA; Martinac B, 2019, 'Mechanosensitivity of Ion Channels', in Encyclopedia of Biophysics, Springer Berlin Heidelberg, pp. 1 - 11,
    Book Chapters | 2018
    Cranfield CG; Kloda A; Nikolaev YA; Martinac AD; Ridone P; Bavi N; Bavi O; Petrov E; Battle AR; Nomura T; Rohde PR; Nakayama Y; Rosholm KR; Cox CD; Baker MA; Martinac B, 2018, 'Mechanosensitivity of Ion Channels', in Encyclopedia of Biophysics, Springer Berlin Heidelberg, pp. 1 - 11,
    Book Chapters | 2017
    Booth TJ; Baker MAB, 2017, 'Nanotechnology: Building and Observing at the Nanometer Scale', in Pharmacognosy Fundamentals Applications and Strategy, pp. 633 - 643,
    Book Chapters | 2016
    Baker MAB, 2016, 'How biophysics may help us understand the flagellar motor of bacteria which cause infections', in Biophysics of Infection, pp. 231 - 243,
  • Journal articles | 2025
    Feng X; Tachiyama S; He J; Zhu S; Zhao H; Botting JM; Liu Y; Chen Y; Hua C; Lara-Tejero M; Baker MAB; Gao X; Liu J; Gao B, 2025, 'The architecture, assembly, and evolution of a complex flagellar motor.', bioRxiv,
    Journal articles | 2025
    Philip JS; Grewal S; Scadden J; Puente-Lelievre C; Matzke NJ; McNally L; Baker MAB, 2025, 'Mapping the loss of flagellar motility across the tree of life', Isme Journal, 19,
    Journal articles | 2024
    Baker MAB; Kojima S, 2024, 'Structure, function, and biophysics of bacterial motility and the flagellar motor鈥擨UPAB2024 session commentary', Biophysical Reviews, 16, pp. 537 - 538,
    Journal articles | 2024
    Baker MAB, 2024, 'Meet the IUPAB Councillor: A/Prof Matthew AB Baker (国民彩票 Sydney, Australia)', Biophysical Reviews, 16, pp. 511 - 512,
    Journal articles | 2024
    Elahi Y; Baker MAB, 2024, 'Light Control in Microbial Systems', International Journal of Molecular Sciences, 25,
    Journal articles | 2024
    Hamm JN; Liao Y; von K眉gelgen A; Dombrowski N; Landers E; Brownlee C; Johansson EMV; Whan RM; Baker MAB; Baum B; Bharat TAM; Duggin IG; Spang A; Cavicchioli R, 2024, 'The parasitic lifestyle of an archaeal symbiont', Nature Communications, 15,
    Journal articles | 2024
    Mason AF; Wickham SFJ; Baker MAB, 2024, 'DIB-BOT: An Open-Source Hardware Approach for Plate-Integrated Droplet Interface Bilayer Deposition', Advanced Materials Interfaces, 11,
    Journal articles | 2024
    Ridone P; Baker MAB, 2024, 'Hybrid Exb/Mot stators require substitutions distant from the chimeric pore to power flagellar rotation', Journal of Bacteriology, 206,
    Journal articles | 2023
    Gurung JP; Navvab Kashani M; de Silva CM; Baker MAB, 2023, 'Microbial stir bars: Light-activated rotation of tethered bacterial cells to enhance mixing in stagnant fluids', Biomicrofluidics, 17,
    Journal articles | 2023
    Islam MI; Ridone P; Lin A; Michie KA; Matzke NJ; Hochberg G; Baker MAB, 2023, 'Ancestral reconstruction of the MotA stator subunit reveals that conserved residues far from the pore are required to drive flagellar motility', Microlife, 4,
    Journal articles | 2023
    Mandal A; Priyam S; Chan HH; Gouveia BM; Guitera P; Song Y; Baker MAB; Vafaee F, 2023, 'Computer-Aided Diagnosis of Melanoma Subtypes Using Reflectance Confocal Images', Cancers, 15,
    Journal articles | 2023
    Nandel V; Scadden J; Baker MAB, 2023, 'Ion-Powered Rotary Motors: Where Did They Come from and Where They Are Going?', International Journal of Molecular Sciences, 24,
    Journal articles | 2023
    Ridone P; Winter DL; Baker MAB, 2023, 'Tuning the stator subunit of the flagellar motor with coiled-coil engineering', Protein Science, 32,
    Journal articles | 2022
    Baker MAB; Kojima S; Nord AL; Partridge JD, 2022, 'Editorial: Flagellar Motors and Force Sensing in Bacteria', Frontiers in Microbiology, 13,
    Journal articles | 2022
    Li J; Jamieson WD; Dimitriou P; Xu W; Rohde P; Martinac B; Baker M; Drinkwater BW; Castell OK; Barrow DA, 2022, 'Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation', Nature Communications, 13,
    Journal articles | 2022
    Ridone P; Ishida T; Lin A; Humphreys DT; Giannoulatou E; Sowa Y; Baker MAB, 2022, 'The rapid evolution of flagellar ion selectivity in experimental populations of E. coli', Science Advances, 8,
    Journal articles | 2021
    Annabi N; Baker M; Boettiger A; Chakraborty D; Chen Y; Corbett KS; Correia B; Dahlman J; de Oliveira T; Ertuerk A; Yanik MF; Henaff E; Huch M; Iliev ID; Jacobs T; Junca H; Keung A; Kolodkin-Gal I; Krishnaswamy S; Lancaster M; Macosko E; Mart铆nez-N煤帽ez MA; Miura K; Molloy J; Cruz AO; Platt RJ; Posey AD; Shao H; Simunovic M; Slavov N; Takebe T; Vandenberghe LH; Varshney RK; Wang J, 2021, 'Voices of biotech research', Nature Biotechnology, 39, pp. 281 - 286,
    Journal articles | 2021
    Gurung JP; Navvab Kashani M; Agarwal S; Peralta G; Gel M; Baker MAB, 2021, 'Separation and enrichment of sodium-motile bacteria using cost-effective microfluidics', Biomicrofluidics, 15,
    Journal articles | 2021
    Islam MI; Bae JH; Ishida T; Ridone P; Lin J; Kelso MJ; Sowa Y; Buckley BJ; Baker MAB, 2021, 'Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types', ,
    Journal articles | 2021
    Islam MI; Bae JH; Ishida T; Ridone P; Lin J; Kelso MJ; Sowa Y; Buckley BJ; Baker MAB, 2021, 'Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types', Journal of Bacteriology, 203,
    Journal articles | 2021
    Islam MI; Lin A; Lai YW; Matzke NJ; Baker MAB, 2021, 'Corrigendum: Ancestral Sequence Reconstructions of MotB Are Proton-Motile and Require MotA for Motility (Front. Microbiol, (2020), 11, (625837), 10.3389/fmicb.2020.625837)', Frontiers in Microbiology, 12,
    Journal articles | 2021
    Islam MS; Gaston JP; Baker MAB, 2021, 'Fluorescence approaches for characterizing ion channels in synthetic bilayers', Membranes, 11,
    Journal articles | 2021
    Matzke N; Lin A; Stone M; Baker M, 2021, 'Homology between the flagellar export apparatus and ATP synthetase: evidence from synteny predating the Last Universal Common Ancestor', ,
    Journal articles | 2021
    Matzke NJ; Lin A; Stone M; Baker MAB, 2021, 'Flagellar export apparatus and ATP synthetase: Homology evidenced by synteny predating the Last Universal Common Ancestor', Bioessays, 43,
    Journal articles | 2021
    Nieves DJ; Baker MAB, 2021, 'Pushing the super-resolution limit: Recent improvements in microscopy below the diffraction limit', Biochemical Society Transactions, 49, pp. 431 - 439,
    Journal articles | 2021
    Ridone P; Ishida T; Lin A; Humphreys D; Giannoulatou E; Sowa Y; Baker M, 2021, 'The rapid evolution of flagellar ion-selectivity in experimental populations ofE. coli', ,
    Journal articles | 2021
    Singh JKD; Darley E; Ridone P; Gaston JP; Abbas A; Wickham SFJ; Baker MAB, 2021, 'Binding of DNA origami to lipids: Maximizing yield and switching via strand displacement', Nucleic Acids Research, 49, pp. 10835 - 10850,
    Journal articles | 2021
    Singh JKD; Darley E; Ridone P; Gaston JP; Abbas A; Wickham SFJ; Baker MAB, 2021, 'Erratum: Binding of DNA origami to lipids: Maximizing yield and switching via strand displacement (Nucleic Acids Res (2021) 49:9 (10835-10850) DOI: 10.1093/nar/gkab888)', Nucleic Acids Research, 49, pp. 12600,
    Journal articles | 2021
    Singh JKD; Luu MT; Berengut JF; Abbas A; Baker MAB; Wickham SFJ, 2021, 'Minimizing cholesterol-induced aggregation of membrane-interacting dna origami nanostructures', Membranes, 11,
    Journal articles | 2020
    Daljit Singh JK; Darley E; Ridone P; Gaston J; Abbas A; Wickham SFJ; Baker MAB, 2020, 'Binding of DNA origami to lipids: maximising yield and switching via strand-displacement', ,
    Journal articles | 2020
    Gurung J; Kashani MN; Agarwal S; Peralta G; Gel M; Baker MAB, 2020, 'Separation and enrichment of sodium-motile bacteria using cost-effective microfluidics', ,
    Journal articles | 2020
    Gurung JP; Gel M; Baker MAB, 2020, 'Microfluidic techniques for separation of bacterial cells via taxis', Microbial Cell, 7, pp. 66 - 79,
    Journal articles | 2020
    Islam MI; Lin A; Lai YW; Matzke NJ; Baker MAB, 2020, 'Ancestral Sequence Reconstructions of MotB Are Proton-Motile and Require MotA for Motility', Frontiers in Microbiology, 11,
    Journal articles | 2020
    Lai YW; Ridone P; Peralta G; Tanaka MM; Baker MAB, 2020, 'Evolution of the stator elements of rotary prokaryote motors', Journal of Bacteriology, 202,
    Journal articles | 2019
    Baker M; Nieves D; Hilzenrat G; Berengut J; Gaus K; Lee L, 2019, 'Stoichiometric quantification of spatially dense assemblies with qPAINT', ,
    Journal articles | 2019
    Baker MAB; Brown AJ, 2019, 'A detour to sterol synthesis', Nature Microbiology, 4, pp. 214 - 215,
    Journal articles | 2019
    Baker MAB; Nieves DJ; Hilzenrat G; Berengut JF; Gaus K; Lee LK, 2019, 'Stoichiometric quantification of spatially dense assemblies with qPAINT', Nanoscale, 11, pp. 12460 - 12464,
    Journal articles | 2019
    Baker MAB, 2019, 'ABA/ASB biophysics and medicine session 2018', Biophysical Reviews, 11, pp. 273 - 274,
    Journal articles | 2019
    Darley E; Singh JKD; Surace NA; Wickham SFJ; Baker MAB, 2019, 'The fusion of lipid and DNA nanotechnology', Genes, 10,
    Journal articles | 2019
    Ishida T; Ito R; Clark J; Matzke NJ; Sowa Y; Baker MAB, 2019, 'Sodium-powered stators of the bacterial flagellar motor can generate torque in the presence of phenamil with mutations near the peptidoglycan-binding region', Molecular Microbiology, 111, pp. 1689 - 1699,
    Journal articles | 2019
    Jaggers OB; Ridone P; Martinac B; Baker MAB, 2019, 'Fluorescence microscopy of piezo1 in droplet hydrogel bilayers', Channels, 13, pp. 102 - 109,
    Journal articles | 2019
    Nieves DJ; Hilzenrat G; Tran J; Yang Z; MacRae HH; Baker MAB; Gooding JJ; Gaus K, 2019, 'tagPAINT: covalent labelling of genetically encoded protein tags for DNA-PAINT imaging', , pp. 604462,
    Journal articles | 2019
    Nieves DJ; Hilzenrat G; Tran J; Yang Z; MacRae HH; Baker MAB; Justin Gooding J; Gaus K; Gooding J, 2019, 'TagPaint: Covalent labelling of genetically encoded protein tags for DNA-PAINT imaging', Royal Society Open Science, 6, pp. 191268,
    Journal articles | 2018
    Baker MAB; Tuckwell AJ; Berengut JF; Bath J; Benn F; Duff AP; Whitten AE; Dunn KE; Hynson RM; Turberfield AJ; Lee LK, 2018, 'Dimensions and Global Twist of Single-Layer DNA Origami Measured by Small-Angle X-ray Scattering', ACS Nano, 12, pp. 5791 - 5799,
    Journal articles | 2018
    Ishida T; Ito R; Clark J; Matzke N; Sowa Y; Baker MAB, 2018, 'Sodium-powered stators of the bacterial flagellar motor can generate torque in the presence of phenamil with mutations near the peptidoglycan-binding region', ,
    Journal articles | 2018
    Jaggers O; Ridone P; Martinac B; Baker M, 2018, 'Fluorescence Microscopy of Piezo1 in Droplet Hydrogel Bilayers', ,
    Journal articles | 2018
    Lin G; Baker MAB; Hong M; Jin D, 2018, 'The Quest for Optical Multiplexing in Bio-discoveries', Chem, 4, pp. 997 - 1021,
    Journal articles | 2018
    Nichols JA; Herbert Chan HW; Baker MAB, 2018, 'Machine learning: applications of artificial intelligence to imaging and diagnosis.', Biophys Rev, 11, pp. 111 - 118,
    Journal articles | 2018
    Nieves DJ; Gaus K; Baker MAB, 2018, 'DNA-based super-resolution microscopy: DNA-PAINT', Genes, 9,
    Journal articles | 2018
    Zhao Z; Zhao Y; Zhuang XY; Lo WC; Baker MAB; Lo CJ; Bai F, 2018, 'Frequent pauses in Escherichia coli flagella elongation revealed by single cell real-Time fluorescence imaging', Nature Communications, 9,
    Journal articles | 2017
    Chen M; Zhao Z; Yang J; Peng K; Baker MAB; Bai F; Lo CJ, 2017, 'Length-dependent flagellar growth of vibrio alginolyticus revealed by real time fluorescent imaging', Elife, 6,
    Journal articles | 2017
    Lee LKY; Baker M; Liew CW; Xu S; Berengut J, 2017, 'Artificial synthesis of supramolecular protein structures', ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 73, pp. C784 - C784,
    Journal articles | 2017
    Rosholm KR; Baker MAB; Ridone P; Nakayama Y; Rohde PR; Cuello LG; Lee LK; Martinac B; Baker M, 2017, 'Activation of the mechanosensitive ion channel MscL by mechanical stimulation of supported Droplet-Hydrogel bilayers', Scientific Reports, 7, pp. 45180,
    Journal articles | 2016
    Al-Zyoud WA; Hynson RMG; Ganuelas LA; Coster ACF; Duff AP; Baker MAB; Stewart AG; Giannoulatou E; Ho JWK; Gaus K; Liu D; Lee LK; B枚cking T; Baker M, 2016, 'Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site', Nucleic Acids Research, 44, pp. 1411 - 1420,
    Journal articles | 2016
    Alcock F; Stansfeld PJ; Basit H; Habersetzer J; Baker MA; Palmer T; Wallace MI; Berks BC, 2016, 'Assembling the Tat protein translocase', Elife, 5,
    Journal articles | 2016
    Alcock F; Stansfeld PJ; Basit H; Habersetzer J; Baker MA; Palmer T; Wallace MI; Berks BC, 2016, 'Assembling the Tat protein translocase', Elife, 5,
    Journal articles | 2016
    Baker MAB; Hynson RMG; Ganuelas LA; Mohammadi NS; Liew CW; Rey AA; Duff AP; Whitten AE; Jeffries CM; Delalez NJ; Morimoto YV; Stock D; Armitage JP; Turberfield AJ; Namba K; Berry RM; Lee LK, 2016, 'Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor', Nature Structural and Molecular Biology, 23, pp. 197 - 203,
    Journal articles | 2016
    Ma Q; Sowa Y; Baker MAB; Bai F, 2016, 'Bacterial Flagellar Motor Switch in Response to CheY-P Regulation and Motor Structural Alterations', Biophysical Journal, 110, pp. 1411 - 1420,
    Journal articles | 2016
    Pu Y; Zhao Z; Li Y; Zou J; Ma Q; Zhao Y; Ke Y; Zhu Y; Chen H; Baker MAB; Ge H; Sun Y; Xie XS; Bai F, 2016, 'Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells', Molecular Cell, 62, pp. 284 - 294,
    Journal articles | 2015
    Xue R; Ma Q;