Professor Daniel Chan and his research team in the Aged Care Department of Bankstown-Lidcombe Hospital have been actively involved in the improvement of lives of older people through research projects aimed at “innovative solutions to unresolved areas” related to diseases or care of older people. They use an approach of combining basic science (geroscience) and translational research in order to offer the best chance of solving these “hard to crack nuts”.
Current research projects include:
- Parkinson’s disease – Plasma biomarkers of Parkinson’s disease for early accurate diagnosis and predicting cognitive impairment. Some of these biomarkers may have protective properties against Parkinson’s disease and its progression.
- Vascular dementia – 1) Plasma biomarkers indicating high risk for neuroinflammation causing small vessel vascular dementia 2) association of genetic polymorphisms in tight-junction proteins and environmental factors in the vascular dementia, 3) collaborative studies looking at the possible treatment of vascular dementia.
- Digital health - Using digital care technologies on falls prevention in older people especially in those with cognitive impairment in healthcare settings. First randomised controlled trial using video clips to help communicate safety message to cognitively impaired patients in hospital setting resulted in 50% less falls in those who were frail or with dementia.
- Geriatric outreach services - Establishing and improving an acute outreach service to aged care facilities and evaluating the impact of such service on patients’ emergency department presentations, admissions to hospital and health economic savings. Preliminary results showed a huge “economical benefit ratio of 1:5” when the new model of acute outreach services to aged care facilities was compared to hospital model.
Our goals
To investigate the biomarkers for early diagnosis of Parkinson’s disease and vascular dementia and possible cure of these neurodegenerative diseases.
To reduce the incidence of falls using new digital technology, so that chemical or physical restraints for at risk of fall people can be avoided.
To improve the delivery of healthcare services for older people in health or care settings via innovative ideas and to prove the efficacy and safety of new models.
Research strengths
By combining basic science with translational research, we have a unique strength to solve “not yet resolved research areas”.
Multi-disciplinary Team with basic scientists and clinicians.
Effective networks of collaborative research – national and international
Our results
Plasma biomarkers for diagnosis and cognitive impairment prediction of Parkinson’s disease have been published (Molecular neurobiology 2022; Journal of Neurology 2022). The biomarkers include preventive indicators which may slow the progress of the disease.
Preventing falls and improving healthcare services in older people.
